Alcohols and polyols

Organic compounds containing one or more hydroxyl functional groups bonded to a carbon atom; hydroxyls consist of an oxygen atom bonded to a hydrogen atom. Alcohols exist in chain, or as closed rings. Polyols contain two or more hydroxyl groups.

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6,106 – 6,120 of 6,657 results

6,106

Medchemexpress LLC Vatinoxan (hydrochloride) | 130466-38-5 | 99.8% | 454.97 | 50 MG

Vatinoxan hydrochloride is a peripheral α2 adrenergic receptor antagonist. It is for research use only and may be useful in attenuating reductions in heart rate.

Increases cardiac index and tissue oxygen delivery without adverse effects.
Attenuates or prevents dexmedetomidine's systemic hemodynamic effects in a dose-dependent manner.
Induces the least alterations in cardiovascular function at a 50:1 dose ratio (Vatinoxan:dexmedetomidine).
Attenuates bradycardia associated with dexmedetomidine.
Shortens sedative effect without altering its quality.

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6,107

Medchemexpress LLC N,N-Dimethyl-3-(5-(2-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-indol-1-yl)propan-1-amine hydrochloride | 97.0% | C20H24ClN5O2S | 50 MG

DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. It demonstrates remarkable inhibition against leukemia cell proliferation and is suitable for laboratory research. The compound shows minimal effects on normal cells.

Inhibits BPTF with an IC50 value of 698 nM
Shows remarkable inhibition against leukemia cell proliferation
Inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM
Significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM)
Decreases downstream oncogene expression at concentrations between 2.5-20 μM
Dose-dependently decreases c-Myc protein level
Shows minimal effects on normal cells, indicating its safety

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6,108

Medchemexpress LLC PRT062607 hydrochloride (P505-15 hydrochloride) | 1370261-97-4 | C19H24ClN9O | 1 ML

PRT062607 Hydrochloride (P505-15 Hydrochloride) is an orally available Syk inhibitor with an IC50 of 1 nM. It inhibits inflammation and induces apoptosis, demonstrating potent antitumor activity in tumor xenograft mouse models. In vitro, it also exhibits significant activity against a variety of kinases, including Fgr, MLK1, Yes, Flt3, PAK5, Lyn, cSRC, Lck, Pyk, and FAK.

Inhibits phosphorylation of ERK(Y204), AKT(S473), and SYK(Y352) in Ramos cells
Inhibits BLNK Tyr84 phosphorylation
Induces apoptosis in human whole blood
Shows dose-dependent anti-inflammatory activity in rodent models of rheumatoid arthritis
Inhibits B-cell activation
Prevents tumor formation in mouse xenograft models

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6,109

Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG

EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. This compound reduces levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression. It selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.

Effective and selective DOT1L inhibitor
Reduces H3K79me2 and H3K79me1 levels
Down-regulates HOXA9 and MEIS1 expression
Selectively inhibits MLL rearrangement cell proliferation
Promotes differentiation and apoptosis of leukemia cells
Potent DOT1L enzyme activity inhibition (IC50 of 400±100 pM)
Demonstrates selectivity over other histone methyltransferases (HMTs)

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6,110

eMolecules 29671-92-9 | Chloroformamidine hydrochloride | Oakwood Chemicals | MFCD00035527 | 114.960 | CH4Cl2N2 | 97.000 | Cl.NC(Cl)=N | 1g | 480138803

Chloroformamidine hydrochloride | Oakwood Chemicals | 29671-92-9 | MFCD00035527 | 114.960 | CH4Cl2N2 | 97.000 | Cl.NC(Cl)=N | 1g | 480138803

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6,111

Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | MFCD31731608 | 99.9% | 430.32 g/mol | C20H23Cl2F2N3O | 10 MG

Befiradol hydrochloride is a selective 5-HT1A receptor agonist provided for research use. It modulates serotonergic and dopaminergic activity in cortical regions and is used in preclinical pharmacology studies to investigate 5-HT1A-mediated mechanisms and models of neurological disorders. The material is supplied with supporting documentation for analytical and safety purposes.

Selective 5-HT1A receptor agonist for receptor pharmacology studies.
Demonstrated activity on dorsal raphe and medial prefrontal cortex neurotransmission.
High chemical purity suitable for analytical and in vivo research.
Supplied with certificate of analysis and safety data sheet.
Available in multiple pack sizes for small-scale and bulk use.
Not for human or clinical use; for research use only.

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6,112

eMolecules 51285-26-8 | Picolinimidamide hydrochloride | ChemScene | MFCD00052271 | 157.600 | C6H8ClN3 | 95.000 | Cl.NC(=N)c1ccccn1 | 25g | 572163656

Picolinimidamide hydrochloride | ChemScene | 51285-26-8 | MFCD00052271 | 157.600 | C6H8ClN3 | 95.000 | Cl.NC(=N)c1ccccn1 | 25g | 572163656

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6,113

Medchemexpress LLC 1H-Indene-1,3(2H)-dione, 2,2-dihydroxy- | 485-47-2 | 100.0 % | 100 G

Ninhydrin is a chromogenic analytical probe used for the quantification of amino acids and proteins. It reacts with primary and secondary amines, producing a blue or purple reaction product, diketohydrindylidene-diketohydrindamine. It is utilized in the amino acid analysis of proteins; most amino acids, excluding proline, can be hydrolyzed and react with ninhydrin, after which they are colorimetrically quantified following chromatographic separation.

Chromogenic analytical probe.
Reacts with primary and secondary amines.
Solid appearance, white to light yellow color.
Quantification of amino acids and proteins.
Useful in amino acid analysis of proteins.

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6,114

Medchemexpress LLC Eperisone (hydrochloride) | 56839-43-1 | 99.95% | 1 G

Eperisone hydrochloride is an orally active antispastic agent with a vasodilator effect. It is used for the research of muscle stiffness and pain. This compound is a potent and selective P2X7 receptor antagonist, also exhibiting antagonism for human P2X3. It works by relaxing both skeletal muscles and vascular smooth muscles, demonstrating several beneficial effects.

Reduces myotonia.
Improves circulation.
Suppresses the pain reflex.
Preferentially suppresses lung fibroblast activity.
Suppresses bleomycin-dependent pulmonary fibrosis.
Not toxic to alveolar epithelial cells in vitro.

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6,115

Medchemexpress LLC Buspirone (hydrochloride) | 33386-08-2 | 99.99 % | 1 G

Buspirone hydrochloride is a 5-HT1A receptor agonist that can be used for anxiety and depression research.

Has cytotoxic effect in lymphocytes.
Induces ROS formation, MMP collapse, lipid peroxidation, lysosomal damage, and elevation of glutathione disulfide (GSSG) in lymphocytes.
Reduces anxiety/depression behaviors in C57BL/6N mice.
Restores IS-shifted β-diversity in the gut microbiota in C57BL/6N mice.
Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus.
Reduced myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon.
Reduced the IS- or EC-induced gut proteobacteria population.

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6,116

Medchemexpress LLC Lecozotan hydrochloride | 433282-68-9 | 98.7% | 520.02 | 5 MG

Lecozotan hydrochloride (SRA-333) hydrochloride is an orally active and selective antagonist of 5-HT1A with a Ki of 4.5 nM for cloned human 5-HT1A receptor. It enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. This product has the potential for mild-to-moderate Alzheimer's disease (AD) research.

Orally active and selective 5-HT1A antagonist.
Enhances the release of glutamate and acetylcholine in the hippocampus.
Possesses cognitive-enhancing properties.
Potential for mild-to-moderate Alzheimer's disease research.

Pricing & Availability

6,117

Medchemexpress LLC Ponatinib hydrochloride | 1114544-31-8 | 99.8% | 569.02 | 25 MG

Ponatinib hydrochloride, also known as AP24534 hydrochloride, is an orally active multi-targeted kinase inhibitor. It inhibits various kinases with IC50s including 0.37 nM for Abl, 1.1 nM for PDGFRα, 1.5 nM for VEGFR2, 2.2 nM for FGFR1, and 5.4 nM for Src.

Purity of 99.76%
CAS number: 1114544-31-8
Molecular weight: 569.02
Appears as an off-white to light yellow solid
Soluble in DMSO at 25 mg/mL
Targets Bcr-Abl, FGFR, PDGFR, VEGFR, Src, and Autophagy pathways
Store at 4°C, sealed, away from moisture; in solvent, store at -80°C for 6 months or -20°C for 1 month

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6,118

Medchemexpress LLC AR-C102222 hydrochloride | 1781934-50-6 | 99.8% | 10MM 1ML

AR-C102222 hydrochloride | 1781934-50-6 | 99.8% | 10MM 1ML

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6,119

Medchemexpress LLC Cl-amidine hydrochloride | 1373232-26-8 | MFCD22201084 | 99.8% | 347.24 | C14H20Cl2N4O2 | 1 ML

Cl-amidine hydrochloride is an orally active peptidylarginine deiminase (PAD) inhibitor used in biochemical, cellular, and in vivo research to block protein citrullination and probe PAD-related pathways.

Inhibits PAD1, PAD3, and PAD4 with reported IC50 values of 0.8 μM, 6.2 μM, and 5.9 μM.
Available as a 10 mM solution in DMSO or as solid quantities for formulation flexibility.
High purity (~99.8%) suitable for biochemical and cellular assays.
Demonstrated activity in cell apoptosis and neutrophil extracellular trap formation assays.
Shows efficacy in murine models of colitis and sepsis in published studies.
Provided supporting documents: data sheet, SDS, COA, HNMR, RP-HPLC, and LCMS.

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6,120

Medchemexpress LLC Antalarmin hydrochloride | 220953-69-5 | MFCD05664721 | 99.9% | 415.01 g/mol | C24H35ClN4 | 1 ML

Antalarmin hydrochloride is a non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist used in research to suppress CRH-induced ACTH secretion and to study stress- and inflammation-related responses in animal models.

Selective CRHR1 antagonist with reported Ki ≈ 1 nM.
CAS number 220953-69-5.
Molecular formula C24H35ClN4, MW 415.01 g/mol.
Available as a solid or as a 10 mM solution in DMSO (1 mL).
High purity (~99.9%) suitable for analytical and in vivo preparations.
Recommended storage: solid at -20°C; in solvent store at -80°C for long term.

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Alcohols and polyols

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Medchemexpress LLC Vatinoxan (hydrochloride) | 130466-38-5 | 99.8% | 454.97 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N,N-Dimethyl-3-(5-(2-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-indol-1-yl)propan-1-amine hydrochloride | 97.0% | C20H24ClN5O2S | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PRT062607 hydrochloride (P505-15 hydrochloride) | 1370261-97-4 | C19H24ClN9O | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | MFCD31731608 | 99.9% | 430.32 g/mol | C20H23Cl2F2N3O | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1H-Indene-1,3(2H)-dione, 2,2-dihydroxy- | 485-47-2 | 100.0 % | 100 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Eperisone (hydrochloride) | 56839-43-1 | 99.95% | 1 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Buspirone (hydrochloride) | 33386-08-2 | 99.99 % | 1 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Lecozotan hydrochloride | 433282-68-9 | 98.7% | 520.02 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ponatinib hydrochloride | 1114544-31-8 | 99.8% | 569.02 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC AR-C102222 hydrochloride | 1781934-50-6 | 99.8% | 10MM 1ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cl-amidine hydrochloride | 1373232-26-8 | MFCD22201084 | 99.8% | 347.24 | C14H20Cl2N4O2 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Antalarmin hydrochloride | 220953-69-5 | MFCD05664721 | 99.9% | 415.01 g/mol | C24H35ClN4 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More